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中国でヒトに感染した鳥インフルエンザA(H7N
9
) ウイルスの性状，検査系の開発およびワクチン開発とその問題点

小田切孝人, 田代眞人

ウイルス
2013年 63 巻 2 号 233-240
発行日: 2013/12/25
公開日: 2014/10/31

DOI https://doi.org/10.2222/jsv.63.233

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英国における過去半世紀 (1922～1972) 間の冶金用コークスの研究

George W. Lee

燃料協会誌
1973年 52 巻 3 号 171-177
発行日: 1973/03/20
公開日: 2010/06/28

DOI https://doi.org/10.3775/jie.52.171

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より実用的な飛行機への探求

Grover Loening

日本航空学会誌
1963年 11 巻 119 号 373-380
発行日: 1963年
公開日: 2009/05/25

DOI https://doi.org/10.2322/jjsass1953.11.373

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Prevalence and molecular characterization of extended-spectrum β-lactamase (ESBL) and plasmidic AmpC β-lactamase (pAmpC) producing Escherichia coli in dogs

Özkan ASLANTAŞ, Ebru Şebnem YILMAZ

Journal of Veterinary Medical Science
2017年 79 巻 6 号 1024-1030
発行日: 2017年
公開日: 2017/06/16
[早期公開] 公開日: 2017/04/27

DOI https://doi.org/10.1292/jvms.16-0432

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This study aimed to determine the prevalence of fecal carriage of extended spectrum β-lactamase (ESBL) and/or plasmidic AmpC β-lactamase (pAmpC) producing Escherichia coli among dogs (n=428) in Turkey. Polymerase chain reaction (PCR) and sequencing were used to characterize genes encoding β-lactamase and plasmid mediated quinolone resistance (PMQR). Antimicrobial susceptibility testing and PCRs for virulence genes and phylogenetic groups were also performed. Cefotaxime resistant
E
. coli isolates were detected in 95 (
22
.2%) of the swab samples. Sequencing analysis results showed occurrence of various β-lactamase genes: bla_CTX-M-15 (62), bla_{TEM-1b
(42), bla_CMY-2 (22
), bla_CTX-M-3 (16), bla_CTX-M-1 (15), bla_OXA-1 (9
) and bla_SHV-12 (3) alone or in combination. The most frequently encountered phylogenetic group was group A₁ (35.8
%), followed by group D₂ (22
.1%), B
1 (15.8
%), D₁ (9
.5
%), A₀ (7.4
%), B2₂
(5
.3%) and B2₃
(4
.2%), respectively. PMQR genes, aac(6’)-Ib-cr, qnrS1 and qnrB10 were detected in 25.3, 10.5
and 1.1% of the isolates, respectively. While all isolates were susceptible to imipenem and amikacin, resistance rates to non-β-lactam antibiotics ranged from 20.0% for tobramycin to 56.8
% for tetracycline. The virulence genes were only detected in 34 (36.2%) of the isolates and this isolates carried single or various combination of virulence genes of iucD, papC, papE, f17a
-A and eaeA. Four isolates were identified as human virulent pandemic CTX-M-15 producing E
. coli clone O25b
:ST131/B
2. To the best of our knowledge, this is the first study to show fecal carriage of ESBL/pAmpC type β-lactamase producing E
. coli isolates among dogs in Turkey.
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緑膿菌感染症の研究

泌尿器科領域における臨床分離株と環境分離株に関する疫学的検討

鎌田日出男

日本泌尿器科學會雑誌
1979年 70 巻 10 号 1142-1158
発行日: 1979/10/20
公開日: 2010/07/23

DOI https://doi.org/10.5980/jpnjurol1928.70.10_1142

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1) P. aeruginosa has been consistently isolated from 26.
5
to 42.
4
% of the patients with urinary tract infections in the urological ward of Okayama University Hospital for the past 7 years. 232 (
22
.3%) out of 1042 hospitalized patients were with urinary tract infections with P. aeruginosa for past
4
years. Of these, 149 (64.2%) were thought to be the catheter induced urinary tract infections. The mode of spreading of this organism was epidemiologically investigated.
2) The following three laboratory assays were used for identification of P. aeruginosa isolated from clinical and environmental strains; serological typing, antibiotic sensitivity and protease and elastase production. Serological typing with 13 immunodiagnostic sera (Toshiba Chemical Industry) was performed by slide agglutination method. Protease and elastase production were detected by the method described by Goto et al.
In combination with serological typing and antibiograms, protease and elastase production offers the finest means of differentiating the strains of P. aeruginosa.
3) Of 136 clinical strains of P. aeruginosa,
89
.7% were serotypable strains. Serotype K was the most prevalent (36.0%), followed by serotype
E
(28.7%),
F
(10.3%) and A (7.
4
%). Most of serotype
F
and
B
which were concurrently isolated from patients in 1976 had the same patterns of antibiogram and production of protease and elastase. It was strongly suggested that these patients were nosocomially cross-infected with the P. aeruginosa from the catheterization or through instrumentation.
4
) Of 354 environmental specimens, 78 P. aeruginosa (
22
.
8
%) were isolated, which were frequently isolated from floor mops and sink-drains. Of these strains, 87.2% were serotypable strains. Serotype
E
was the most prevalent (42.3%), followed by serotype K (24.
4
%) and
B
(12.
8
%). The same strains were seldom detected at the same sources successively, but different types of P. aeruginosa were usually detected. Among the serotypes
E
,
F
and K, 18 strains (23.1%) were identical with the clinical strains. All of these were found during or after the clinical outbreaks of P. aeruginosa infections. There was no environmental strains that caused clinical infections. The other 60 strains (76.
9
%) were different from the clinical strains, and present only transiently in the hospital environments.
5
) Both clinical and environmental strains similary produced protease and elastase at 70 to 80%, hemolysin at 100%. Only 10 out of 37 environmental strains (27.0%) were found to produced exotoxin.
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71(P2-1) 軟サンゴ、オオウミキノコからの新センブラン型ジテルペン類の構造と分子内閉環反応(ポスター発表の部)

小林優, 家坂貴子, 中野江身子, 平山耕一郎

天然有機化合物討論会講演要旨集
1989年 31 巻 71/P2-1
発行日: 1989/09/17
公開日: 2017/08/18

DOI https://doi.org/10.24496/tennenyuki.31.0_540

会議録・要旨集フリー

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Six new cembranoids sarcophytol P (3), R (
4
), S (
5
), K (
8
),
F
(11), and T (13) were isolated from the soft coral Sarcophyton glaucum. Sarcophytol P (3) was shown to be the 20-hydroxy derivative of the major component sarcophytol A (1), and afforded the cyclization product 6 in CHCl_3 at room temperature, in a same way as in 1. Sarcophytols R (
4
) and S (
5
) were correlated to 1, by conversion of its 7R,
8
R and 7S,
8
S epoxide derivatives. Sarcophytol K(
8
) was a 13, 14-dihydroxycembranoid having a 1
E
,3Z-diene moiety. The absolute configuration of
8
and its 1Z,3
E
- and 1Z,3Z-isomers sarcophytol
B
(2) and J (10) were determined by circular dichroism study of their bis-p-dimethylaminobenzoate derivatives. Sarcophytols
F
(11) and T (13) were 1
E
- and 1
E
,3Z-isomers of 1. Compound 11 showed characteristic broadening of the ^1H-NMR chemical shifts, due to the restricted conformational interconversion. Using the three cembranoids sarcophytols
F
(11, 1
E
,3
E
), N (15, 1Z,3Z) and T (13,1
E
,3Z), spontaneous autoxidation-cyclization, in CHCl_3,was examined, in order to compare the stereochemical course of the reaction with that of 1 (1Z,3
E
), which affords trans-fused bicyclo[
9
.3.0]tetradecene systems. The 1
E
,3Z-isomer 13 gave the same cyclization product 18, as in the reaction of 1, even though it is isomeric at C-1,3. The 1Z,3Z isomer 15 gave 19, in consequence of the reversed geometry at C-3 of 15. The 1
E
,3
E
-isomer (11) gave the bicyclic product
22
, having an antipodal fusion as compared with 19. This was confirmed by PCC oxidation of 19 and
22
, giving enantiomeric ketones 23 and 24 respectively. The 1(14)-epoxide 26 was shown to be the immediate precursor of
22
, and acounted for the inversion of the geometry at C-1 of the cyclization product. Compound 26 is isomeric with the epoxide 17 derived from 1. The epoxide 17 is the postulated precursor in the conversion of 13 to 18. It is noteworthy that the mode of antipodal fusion of the cyclopentane rings, in 18 and
22
, was controlled by the chirality of the epoxy rings. The C-14 hydroxyl group participates in the transannular cyclization, but was found not to be the requisite functional group for the reaction. Similar treatment of cembrene C (30), the parent hydrocarbon of 1, also reacted in CHCl_3 giving the bicyclic product 32.
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乳牛の壊疽性乳房炎に関する研究

II. 細菌学的検査

函城悦司, 蓬莱英造, 入谷晋市, 柏崎守, 久米常夫

日本獣医師会雑誌
1980年 33 巻 10 号 485-489
発行日: 1980/10/20
公開日: 2011/06/17

DOI https://doi.org/10.12935/jvma1951.33.485

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壊疽性乳房炎の病因を探るため, 本症の症例について細菌学的検討を行なったところ次の結果を得た.
発症牛の乳汁の細菌検査では, Escherichia coli 50.
9
%, Pseudomoms aerugimsa 17%とこの両者の菌種が主に分離され, 次いでKlebsiella Pmummiae
4
.6%, Enterobacter aerogenes
4
.6%, Clostridium perfringens
4
.6%, Bacillus clreus
4
.6%, Staphylococcus aureus
4
.6%, Streptococcus sp.
4
.6%, Alcaligenes faecalis 1.
5
%, Acinetobacter anitratus 1.
5
%, Corymbacterium pyogenes 1.
5
%などの検出率であった.
罹患分房および一部の乳房リンパ節から純粋に多数の起因菌を分離したが, 主要臓器からはほとんど分離できなかったことから本症の発生機序が起因菌の菌体毒素の作用によることが疑われる.
分離菌の血清型別は, E
. coliではO²
5
株,
O⁸
, O⁷⁵,
O⁸⁸
それぞれ2株,
O⁹
, O⁶⁴, O⁷⁶,
O⁸⁹
は1株つつであった. またP. alrugimsaは
E
,
F
, I型は2株づつ, A,
B
, Gはそれぞれ1株つつであった.
薬剤感受性試験は, E
. coliではKM, CP, CL, CTC, SM, OTC, FMに感受性があり, P. aeruginosaはCL, SMに比較的感受性であった.
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Lighting Hardware

I.
F
. Davies

Journal of Light & Visual Environment
1984年 8 巻 1 号 1_9-1_20
発行日: 1984年
公開日: 2011/05/20

DOI https://doi.org/10.2150/jlve.8.1_9

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Sterol Constituents from the Fruit Bodies of Grifola frondosa (FR.) S.
F
. Gray

Takaaki ISHIZUKA, Yasunori YAOITA, Masao KIKUCHI

Chemical and Pharmaceutical Bulletin
1997年 45 巻 11 号 1756-1760
発行日: 1997/11/15
公開日: 2008/03/31

DOI https://doi.org/10.1248/cpb.45.1756

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Four new sterols,
5α
, 6α-epoxy-(
22
E
, 24R)-ergosta-
8
(14),
22
-diene-3β, 7β-diol (1), (
22
E
, 24R)-ergosta-
8
,
22
-diene-3β,
5α
, 6β, 7α-tetrol (2), (
22
E
, 24R)-ergosta-7,
9
(11),
22
-triene-3β,
5α
, 6β-triol (3) and 3β,
5α
, 6β-trihydroxy-(
22
E
, 24R)-ergost-
22
-en-7-one (
4
), have been isolated from the fruit bodies of Grifola frondosa (FR.) S.
F
. GRAY (Polyporaceae)together with fourteen known ones (
5
-18), of which two (
5
and 6) are reported for the first time from a natural source. The structures of these compounds were elucidated on the basis of spectral data.
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魚市場およびと畜場のドブネズミ由来黄色ぶどう球菌の性状

加藤行男, 松本智, 潮田弘, 谷川力, 高木敬彦, 光崎研一, 金内長司

日本獣医師会雑誌
1996年 49 巻 6 号 408-410
発行日: 1996/06/20
公開日: 2011/06/17

DOI https://doi.org/10.12935/jvma1951.49.408

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魚市場およびと畜場のドブネズミにおけるStaphylococcus auresの保有率はそれぞれ74.6% (44/59), 34.6% (
9
/26) であった. 魚市場のネズミ由来S. aureus104株の生物型はC型81株 (77.
9
%),
B
型16株 (15.
4
%), A型6株 (
5
.
8
%), 型別不能1株 (1%) で, と畜場由来
9
株はG型
8
株 (
88
.
9
%),
B
型1株 (11.1%) であった. 魚市場のネズミ由来株のコアグラーゼ型は, VIII型 (26.
9
%), 1型 (
22
.1%), VII型 (13.
5
%), IV型 (
8
.7%), II型 (
5
.
8
%), III型 (2.
9
%), V型 (2.
9
%), VI型 (2.
9
%), 同定不能 (14.
4
%) で, と畜場由来株は, VIII型 (44.
4
%), V型 (
22
.2%), VI [型 (
22
.2%), 同定不能 (11.1%) であった.魚市場のネズミ
9
匹由来の12株からはエンテロトキシンA (11株) および
B
(1株) が産生された.
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熱力学諸量の測定とその結果を用いた化学熱力学計算によるNi-Mo-
B
およびNi-W-
B
3成分系状態図の決定

香山滉一郎, 森下政夫, 張国鋒

粉体および粉末冶金
2006年 53 巻 5 号 419-429
発行日: 2006年
公開日: 2006/12/19

DOI https://doi.org/10.2497/jjspm.53.419

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The phase diagrams of the Ni-Mo-
B
and Ni-W-
B
ternary systems in the region of less than 50mol%
B
were constructed by thermodynamic calculation, based on the data obtained by thermodynamic measurement of the related materials. We found three ternary eutectic points and three or two ternary peritecto-eutectic points as follows:
E₁
:L (1365K, 71.
5
mol%Ni-6.0mol%Mo-
22
.
5
mol%
B
)=(Ni)+
Ni₃B
+
NiMo₂B₂

E₂
:L (1355K, 62.
5
mol%Ni-2.
5
mol%Mo-30.
5
mol%
B
)=
Ni₃B
+
Ni₂B
+
NiMo₂B₂

E₃
:L (1445K, 42.0mol%Ni-30.6mol%Mo-10.3mol%
B
)=(Ni)+NiMo+
NiMo₂B₂

P₁:L (1812K, 34.
9
mol%Ni-42.3mol%Mo-
22
.
8
mol%
B
)+MoB=
Mo₂B
+
NiMo₂B₂

P₂:L (1633K, 42.3mol%Ni-40.
4
mol%Mo-17.3mol%
B
)+Mo=
Mo₂B
+
NiMo₂B₂

P₃:L (1812K, 53.
5
mol%Ni-33.7mol%Mo-12.
8
mol%
B
)+Mo=NiMo+
NiMo₂B₂

E₁
:L (1622K, 51.0mol%Ni-31.6mol%W-17.
4
mol%
B
)=(Ni)+W+
NiW₂B₂

E₂
:L (1260K, 71.0mol%Ni-7.0mol%W-
22
.0mol%
B
)=(Ni)+
Ni₃B
+
NiW₂B₂

E₃
:L (1291K, 65.
4
mol%Ni-
4
.
8
mol%W-29.
8
mol%
B
)=
Ni₂B
+
Ni₃B
+
NiW₂B₂

P₁:L (2115K, 23.
8
mol%Ni-43.1mol%W-33.1mol%
B
)+WB=
W₂B
+
NiW₂B₂

P₂:L (1657K, 48.
9
mol%Ni-33.1mol%W-18.0mol%
B
)+
W₂B
=W+
NiW₂B₂

The calculated phase diagrams are expected to be useful for the development of new Ni-based heat-, corrosion- or wear-resistance alloys.
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Isolation and Structures of New Azaphilone Derivatives, Falconensins
E
-G, from Emericella falconensis and Absolute Configurations of Falconensins A-G

Takeshi ITABASHI, Nobuko OGASAWARA, Koohei NOZAWA, Ken-ichi KAWAI

Chemical and Pharmaceutical Bulletin
1996年 44 巻 12 号 2213-2217
発行日: 1996/12/15
公開日: 2008/03/31

DOI https://doi.org/10.1248/cpb.44.2213

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Three new azaphilone derivatives designated falconensins
E
5
(
5
),
F
(6), and G (7) were isolated from the mycelium o Emericella falconensis, along with falconensins A (1),
B
(2), C (3), D (
4
), and H (
8
), and three hopane-type triterpenes, zeorin (
9
), hepane-7β,
22
-diol (10), and hopane-6α, 7β,
22
-triol (11). The structures of
5
-7 were confirmed by spectroscopic investigation and chemical correlations. The absolute stereochemistry of falconensins A (1) to G(7) was also established.
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メイタガレイ仔稚魚の飼育と形態の変化

北島力, 林田豪介, 安元進

魚類学雑誌
1988年 35 巻 1 号 69-77
発行日: 1988/05/25
公開日: 2011/07/04

DOI https://doi.org/10.11369/jji1950.35.69

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Fertilized eggs of Pleuronichthys cornutus were obtained by both artificial fertilization and natural spawning of laboratory-reared fish. The present paper describes in detail the early development of the fish and the rearing methods employed to provide basic information for mass production of this species. Eggs and sperm for artificial fertilization were obtained from adult fish caught in the Ariake Sound, Kyushu in November and December of 1984. Their maturation was successfully induced by intermuscular injection of pituitary homogenate of the silver carp, Hypophthalmichthys molitrix. Fertilized eggs were also obtained in 1985 by natural spawning of a broodstock kept in a tank for a year. Hatched larvae were fed successively with rotifers, Artemia nauplii and the harpacticoid copepod, Tigriopus japonicus and reared for 80 days. Ten thousand young fish of about 33mm TL were obtained in 1984 and 1985 with the survival rate of about 17%. Ten developmental stages were defined on the basis of the morphological characteristics: A) newly hatched to
4
day old larvae, 2.7 to
4
.1mm TL (2.6 to 3.
9
mm NL), yolk sac present;
B
)
4
to 16 day old larvae, 3.
8
to
5
.
9
mm (3.6 to
5
.6mm), yolk resorbed, actively feeding on rotifers; C) 15 to 30 day old larvae, 6.3 to
8
.3mm (6.0 to 7.
9
mm), notochord straight, hypural fin ray visible; D) 24 to 40 day old larvae, 6.7 to
9
.2mm (6.
4
to
8
.
8
mm), caudal notochord upturned (45°);
E
) 28 to 45 day old larvae, 7.
9
to 10.
8
mm (7.
5
to 10.3mm), caudal notochord upturned (45°-90°);
F
) 32 to 50 day old larvae, 10.
8
to 15.7mm (
8
.
8
to 12.
8
mm BL), eyes symmetrical; G) 35 to 66 day old larvae, 13.
4
to 20.0mm (10.
9
to 16.3mm), eyes asymmetrical, but left eye not visible from the right side; H) 40 to 75 day old larvae, 13.
8
to 26.2mm (11.3 to 21.
4
mm), the upper edge of left eye visible over top of the head from the right side; I) 46 to
89
day old larvae, 20.1 to 27.
4
mm (16.
4
to
22
.
4
mm), left eye on the edge of the head and pupil visible from the right side; and J) juveniles of 51 day old or over, 23.6mm or more (19.3mm or more), metamorphosis completed. One to three inflections were found for relative growth of total length, eye diameter, upper jaw length, preanal length, and distance between the base of the pectoral fin and the anus against the notochord length or body length. Two inflections were found for body length (or notochord length)-body weight relationship.Most inflections appeared at the stages of D,
F
and J, corresponding to the body length of
8
,
9
-12 and 18-
22
mm respectively.
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(
22E
, 24S)
5α
-Stigmasta-3,
22
-dien-6-one: An Intermediate of the Isomerization of (
22E
, 24S)-3α,
5
-Cyclo-
5α
-stigmast-
22
-en-6-one into (
22E
, 24S)-
5α
-Stigmasta-2,
22
-dien-6-one

Suguru TAKATSUTO, Kiyomi KOBAYASHI, Tsuyoshi WATANABE, Hiroki KURIYAMA, Tokuo FURUSE

Agricultural and Biological Chemistry
1988年 52 巻 12 号 3217-3218
発行日: 1988年
公開日: 2006/04/05

DOI https://doi.org/10.1271/bbb1961.52.3217

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Allelic variation of LMW-GS composition in Chinese wheat landraces of the Yangtze-River region detected by MALDI-TOF-MS

Yanchun Peng, Zitong Yu, Shahidul Islam, Yujuan Zhang, Xiaolong Wang, Zhensheng Lei, Kan Yu, Dongfa Sun, Wujun Ma

Breeding Science
2016年 66 巻 4 号 646-652
発行日: 2016年
公開日: 2016/09/30
[早期公開] 公開日: 2016/08/11

DOI https://doi.org/10.1270/jsbbs.16050

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電子付録

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Low molecular weight glutenin subunits are important components of wheat storage proteins, which play an important role in determining end-use quality of common wheat. A newly established matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) procedure was used to analyze 478 landraces of bread wheat collected from the Yangtze-River region in China. Results indicated that 17 alleles at three loci: Glu-A3, Glu-
B3
and Glu-D3 were identified, resulting in 87 different allele combinations. Of the 17 alleles detected at all the Glu-3 loci, five belonged to Glu-A3, seven to Glu-
B3
and five to Glu-D3 locus. MALDI-TOF-MS indicated Glu-A3a/c was present in 72.
8
%, Glu-
A3b
in
8
.
4
%, Glu-A3d in
8
.
4
%, Glu-
A3f
in
5
.2% and Glu-
A3e
in 3.6% lines. Seven types of alleles were identified at the Glu-
B3
locus: Glu-
B
3d/i (25.
5
%), Glu-
B3b
(21.3%), Glu-
B3c
(16.
9
%), Glu-
B3h
(13.
8
%), Glu-
B3f
(
8
.
4
%), Glu-
B3a
(
8
.2%), and Glu-
B3g
(
5
.2%). Five types of Glu-D3 alleles were detected: Glu-D3a (58.
4
%), Glu-D3c (
22
.6%), Glu-D3d (15.
5
%), Glu-
D3b
(3.3%) and Glu-
D3f
(0.2%). Four new alleles that showed abnormal MALDI-TOF spectrum patterns were identified at the Glu-A3 and Glu-
B3
loci. A detailed study is needed to further characterize these alleles and their potential usage for wheat improvement.

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Short-Step Synthesis of Plant Growth-Promoting Brassinosteroids

高津戸秀, 池川信夫

Chemical and Pharmaceutical Bulletin
1984年 32 巻 5 号 2001-2004
発行日: 1984/05/25
公開日: 2008/03/31

DOI https://doi.org/10.1248/cpb.32.2001

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Brassinolide analogues, (
22
R, 23R, 24R)-2α, 3α,
22
, 23-tetrahydroxy-
B
-homo-7-oxa-
5α
-ergostan-6-one (24-epibrassinolide) (10) and (
22
S, 23S, 24R)-2α, 3α,
22
, 23-tetrahydroxy-
B
-homo-7-oxa-
5α
-ergostan-6-one (
9
), were synthesized from brassicasterol (3a) in five steps and with ca. 20% overall yield. The key steps are the direct formation of (
22
E
, 24R)-3α,
5
-cyclo-
5α
-ergost-
22
-en-6-one (
4
) from brassicasterol mesylate (3
b
), the acid-catalyzed rearrangement of
4
to (
22
E
, 24R)-
5α
-ergosta-2,
22
-dien-6-one (6), and the Baeyer-Villiger oxidation of the tetrahydroxy
5α
-ergostan-6-ones 7 and
8
.
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眼窩・下内側面の皮質下白質切截術(orbito-ventromedial undercutting)施行前後における Rorschach 反応の分析

橋口英俊

日本医科大学雑誌
1983年 50 巻 4 号 563-585
発行日: 1983/08/15
公開日: 2009/12/04

DOI https://doi.org/10.1272/jnms1923.50.563

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Thirty-six patients (19 males, 17 females: atypical schizophrenia; 3, typical schizophrenia;
9
, depression; 11, neurosis and other psychiatric disorders;
8
) were operated on according to orbitoventromedial undercutting by Hirose. In all cases, the Rorschach test was carried out and daily behaviors were studied. Thirty-one scales of the test were subjected to multivariate analysis whereas the behaviors were evaluated according to the following criteria, i.
e
., A: recovered or symptom free,
B
: markedly improved, C: moderately improved, D: slightly improved and
E
: not improved. The following results were obtained.
1) The evaluation of behaviors is as follows. A: 12 cases,
B
:
9
, C:
9
, D: 6,
E
: none.
2) It was found that scores of
F
+106% and R+106% scales were significantly higher after the operation than before; that correlation coefficients between the scores before and after the operation were considerably high.
3) Factor analysis followed by varimax rotation was carried out. Six factors were extracted, i.
e
., (
F
1) sensitivity to emotional stimuli, (
F
2) ego-strength, (
F
3) obsessional rigidity, (
F
4
) reaction time, (
F
5
) anxiety and tension and (
F
6) empathy. It was revealed that
F
2 was high in atypical schizophrenia, depression and neurosis, and that
F
2 and
F
6 were significantly different in terms of the factor scores among the four groups A,
B
, C and D;
F
2 was highest in A, and lowest in D regardless of whether it was before or after the operation.
F
6 showed high scores in both A and C, and low in D.
4
) Multiple discriminant analysis was applied to the data of the Rorschach test before the operation, by classifying 36 subjects into the four groups A,
B
, C and D. As a result, high rates of correct diagnosis were obtained, i.
e
., 100% for A, 78% for
B
, 56% for C and 100% for D. When the groups C and D were combined into one group (C+D) the highest percentage (100%) was seen in A, followed by
B
(
89
%) and C+D group (87%). When the groups A and
B
were combined into one group (A+
B
), the percentages of correct diagnosis were 81% for A+
B
, and 93% for C+D.
In conclusion, it can be said that scales of the Rorschach test have been proved to be valid for predicting mental and physical states after the orbito-ventromedial undercutting.
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14 新規免疫抑制活性物質mycestericin類D,
E
,
F
およびGの絶対配置の決定と全合成(口頭発表の部)

浜道則光, 藤多哲朗, 松崎徹, 北尾有紀, 城内正寿, 広瀬良治

天然有機化合物討論会講演要旨集
1995年 37 巻 14
発行日: 1995/09/01
公開日: 2017/08/18

DOI https://doi.org/10.24496/tennenyuki.37.0_79

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Mycestericins D (1),
E
(3),
F
(2) and G (
4
), new immunosuppressants, were isolated from the culture broth of Mycelia sterilia ATCC 20349. The immunosuppressive activities of 1 and 2 exhibited an IC_<50> of 16nM and 120nM against mouse allogeneic mixed lymphocyte reaction (MLR), respectively, while 3 and
4
exhibited an IC_<50> of 13nM and 370nM, respectively. The proposed structures were unambiguously confirmed by spectroscopy, chemical evidence and total synthesis. Their absolute configurations have been determined by comparison of their CD spectra with those of synthetic compounds (R and S)-
9
prepared from methyl (2S,
4
R)-2-tert-butyl-3-formyl-oxazolidine-
4
-carboxylate (
5
) and stearoyl chloride. Thus, mycestericins D (1) and
F
(2) were assigned to be 2 (S), 3 (S) configurations, while mycestericins
E
(3) and G (
4
) were 2 (S), 3 (R) configurations. The first total synthesis of mycestericins have been achieved from
5
and 1,
8
-octanediole (10). The alkyl chain moiety 21 was prepared in 12 steps from 10 by straightforward reactioin. The key intermediate
22
obtained from
5
and 21 could be converted to the desired final compounds. Stereoselective reduction of the ketone
22
with Zn(BH_
4
)_2 or NaBH_
4
provided the (R)-hydroxy 23, the protecting groups of which were removed with 10% MeOH in CF_3COOH, followed by hydrolysis of 24 to give mycestericin
E
(3). On the other hand, mycestericin D (1) was synthesized from
22
by deprotection, followed by reduction of 25 with Me_
4
NBH(OAc)_3 and then hydrolysis of 26. Hydrogenation of mycestericin D (1) and
E
(3) provided the corresponding
F
(2) and G (
4
).
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Isolation and Characterization of Phenolic Compounds from Magnoliae Cortex Produced in China

矢原正治, 西依健, 江田昭英, 野原稔弘, 西岡五夫

Chemical and Pharmaceutical Bulletin
1991年 39 巻 8 号 2024-2036
発行日: 1991/08/25
公開日: 2008/03/31

DOI https://doi.org/10.1248/cpb.39.2024

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A chemical examination of Magnoliae Cortex produced in China (Magnolia officinalis REHD. et WIL S., Magnoliaceae) has led to the isolation of eighteen new lignans and related compounds [four monoterpenyl-lignans : piperitylmagnolol (3), dipiperitylmagnolol (
4
), piperitylhonokiol (
5
) and bornylmagnolol (6); seven lignans : magnaldehydes
B
(
8
), C(
9
), magnolignans A(10),
B
(11), C(12), D(13) and
E
(14); three norlignans : magnatriol
B
(16), magnaldehydes D(17) and
E
(18); and four dilignans : magnolignans
F
(19), G(20), H(21) and I(
22
)], together with randainal (7), randaiol (15), sinapic aldehyde, syringaresinol, syringaresinol
4
'-O-β-D-glucopyranoside and 6'-O-methylhonokiol. Their structures were determined by the chemical and spectral methods.
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42 マキ属植物のノルジテルペンジラクトン類の反応と相互変換

林雄二, 松本武

天然有機化合物討論会講演要旨集
1981年 24 巻 42
発行日: 1981/09/10
公開日: 2017/08/18

DOI https://doi.org/10.24496/tennenyuki.24.0_322

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Reactions of nor-diterpenoid dilactones isolated from Podocarpus plants have been investigated. The 7:
8
,
9
: 11-dienolide type [C] dilactones, the least available but biologically the most active members, are mainly derived from naturally abundant dilactone components of α-pyrone type [A] and 7:
8
-epoxy-
9
: 11-enolide type [
B
] for total-synthetic and biological purposes. From nagilactone
E
(
5
), for example, a combined sequence of hydrogenolysis of 7:
8
-epoxide group and dehydration gives nagilactone
F
(7), 3β-hydroxynagilactone
F
(
8
) and 2: 3-dehydronagilactone
F
(19), which have been found from natural sources. From nagilactone A (1), photo-hydration and concomitant double bond migration of its acetate results in a lactol (
22
), which is reduced to 1β-hydroxynagilactone
F
(
9
), another natural type [C] dilactone. Derivation of the type [A] or [
B
] from others is not successful. Some attempts for conversion of the ring A functional groups have also been studied.
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