Anti-uterotropic Activities of 16β-Ethyl-1, 3, 5 (10)-estratrien-3, 17β-diol (16β-ethylestradiol-17β) and Related Compounds

Abstract

Uterotropic and anti-uterotropic activities of 16β-ethylestradiol-17β and their derivatives were examined in immature female rats. By subcutaneous administration, 16β-ethylestradiol-17β demonstrated a high potency in the anti-uterotropic activity but a low potency in the uterotropic activity which was approximately 0.01% of the activity of estradiol-17β in the four-day test.