Antitumor Activity of 4-Nitropyridazine 1-Oxides and Related Compounds for AH-13

SHOZO KAMIYA; MICHIKO ANZAI; TOSHIAKI NAKASHIMA; SHOKO SUEYOSHI; MASAYUKI TANNO; IKUO SUZUKI; MOTOIJr. ISHIDATE; SHIGEYOSHI ODASHIMA

doi:10.1248/cpb.25.504

SHOZO KAMIYA, MICHIKO ANZAI, TOSHIAKI NAKASHIMA, SHOKO SUEYOSHI, MASAYUKI TANNO, IKUO SUZUKI, MOTOIJr. ISHIDATE, SHIGEYOSHI ODASHIMA

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Keywords: reactive 4-nitro groups of 1, 2-diazine N-oxides

JOURNAL FREE ACCESS

1977 Volume 25 Issue 3 Pages 504-506

DOI https://doi.org/10.1248/cpb.25.504

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Abstract

Antitumor activity of 4-nitropyridazine 1-oxides and related compounds was tested with AH-13 system. Among these nitro compounds, 3, 6-dimethoxy-4-nitropyridazine 1-oxide (III) and 4-nitrocinnoline 1-oxide (XIII) were the most effective. 4-Nitropyridazine 1-oxide (I), 3, 6-dimethyl-4-nitropyridazine 1-oxide (II) and 3-alkoxy-4-nitro-6-chloropyridazine 1-oxides (VI, VII) were effective to some extent.

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