The Study on a PVC Membrane Electrode for Gemfibrozil

Fen Xu; Li-Xian Sun; Naoki Matsuda; Tatsuhiro Okada; Zhi-Cheng Tan; Jian-Guo Liang

doi:10.1248/bpb.25.165

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The Study on a PVC Membrane Electrode for Gemfibrozil

Fen Xu, Li-Xian Sun, Naoki Matsuda, Tatsuhiro Okada, Zhi-Cheng Tan, Jian-Guo Liang

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Keywords: gemfibrozil, ion selective electrode, orthogonal experimental design, quantitative determination

JOURNAL FREE ACCESS

2002 Volume 25 Issue 2 Pages 165-167

DOI https://doi.org/10.1248/bpb.25.165

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Abstract

In this paper, a poly(vinyl chloride) (PVC) membrane electrode is prepared for gemfibrozil, 2, 2-dimethyl-5-(2,5-xylyloxy) valeric acid, based on its ion pair complexes with hexadecyltrioctyl ammonium iodide (HTOA). The membrane composition of the electrode was optimized by using the sequential level elimination method for orthogonal experimental design. The electrode has a Nernstian response range from 2.5×l0⁻⁵ to 0.1 mol/l with an average slope of 55.3 mV/decade. The limit of detection is 7.l×l0⁻⁶ mol/l. The electrode responses were not affected by pH in the range 10.0—12.3. A Na₂B₄O₇–Na₂CO₃ buffer of pH=11.0 was selected as the background electrolyte solution for potentiometric measurements. The electrode was used for determining gemfibrozil in pharmaceutical preparations with satisfactory results.

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