Enzymes Inhibiting Lignans from Vitex negundo

Azhar-Ul-Haq; Abdul Malik; Itrat Anis; Sher Bahadar Khan; Ejaz Ahmed; Zaheer Ahmed; Sarfraz Ahmad Nawaz; Muhammad Iqbal Choudhary

doi:10.1248/cpb.52.1269

Regular Articles

Enzymes Inhibiting Lignans from Vitex negundo

Azhar-Ul-Haq, Abdul Malik, Itrat Anis, Sher Bahadar Khan, Ejaz Ahmed, Zaheer Ahmed, Sarfraz Ahmad Nawaz, Muhammad Iqbal Choudhary

Author information

Azhar-Ul-Haq
International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi
Abdul Malik
International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi
Itrat Anis
International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi
Sher Bahadar Khan
International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi
Ejaz Ahmed
International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi
Zaheer Ahmed
International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi
Sarfraz Ahmad Nawaz
International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi
Muhammad Iqbal Choudhary
International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi

Keywords: Vitex negundo, Verbinaceae, lignan, lipoxygenase, cholinesterase inhibition

JOURNAL FREE ACCESS

2004 Volume 52 Issue 11 Pages 1269-1272

DOI https://doi.org/10.1248/cpb.52.1269

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Abstract

Two new lignans trivially named negundins A (1) and B (2), were isolated along with (+)-diasyringaresinol (3), (+)-lyoniresinol (4), vitrofolal E (5) and vitrofolal F (6), reported for the first time from this species. The structures of the new compounds were established through spectral studies. Compound 2 showed potent inhibitory activity against lipoxygenase enzyme, while 5 showed moderate activity against butyryl-cholinesterase.

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