Azaphilone and Isocoumarin Derivatives from the Endophytic Fungus Penicillium sclerotiorum PSU-A13

Jiraporn Arunpanichlert; Vatcharin Rukachaisirikul; Yaowapa Sukpondma; Souwalak Phongpaichit; Supinya Tewtrakul; Nuttawut Rungjindamai; Jariya Sakayaroj

doi:10.1248/cpb.58.1033

Regular Articles

Azaphilone and Isocoumarin Derivatives from the Endophytic Fungus Penicillium sclerotiorum PSU-A13

Jiraporn Arunpanichlert, Vatcharin Rukachaisirikul, Yaowapa Sukpondma, Souwalak Phongpaichit, Supinya Tewtrakul, Nuttawut Rungjindamai, Jariya Sakayaroj

Author information

Keywords: endophytic fungus, Penicillium sclerotiorum, azaphilone, antibacterial activity, antifungal activity, anti-human immunodeficiency virus-1 activity

JOURNAL FREE ACCESS

2010 Volume 58 Issue 8 Pages 1033-1036

DOI https://doi.org/10.1248/cpb.58.1033

Details

Abstract

Two new azaphilone derivatives, penicilazaphilones A (1) and B (2), and one new isocoumarin, penicilisorin (3), together with six known compounds were isolated from the endophytic fungus Penicillium sclerotiorum PSU-A13. Their structures were identified by analysis of spectroscopic data. The antimicrobial activity against Staphylococcus aureus, Candida albicans and Cryptococcus neoformans as well as the inhibitory effect on human immunodeficiency virus (HIV)-1 integrase and protease were examined.

Corresponding author

Register with J-STAGE for free!