Antitumor Principles from Ginkgo biloba L.

HIDER ITOKAWA; NOBUO TOTSUKA; KEISUKE NAKAHARA; KOICHI TAKEYA; JEAN-PIERRE LEPOITTEVIN; YOSHINORI ASAKAWA

doi:10.1248/cpb.35.3016

Antitumor Principles from Ginkgo biloba L.

HIDER ITOKAWA, NOBUO TOTSUKA, KEISUKE NAKAHARA, KOICHI TAKEYA, JEAN-PIERRE LEPOITTEVIN, YOSHINORI ASAKAWA

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Keywords: Ginkgo biloba, Ginkgoaceae, antitumor activity, Sarcoma 180 ascites, anacardic acid, bilobol, cardanol

JOURNAL FREE ACCESS

1987 Volume 35 Issue 7 Pages 3016-3020

DOI https://doi.org/10.1248/cpb.35.3016

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Abstract

Seven long-chain phenols were isolated from Ginkgo biloba L. Three of them, anacardic acid (Ib), bilobol (IIa), and cardanol (IIIa), showed antitumor activity against Sarcoma 180 ascites in mice. The antitumor effectiveness was rated (+ +) for Ib, (+ + +) for IIa, and (+ + +) for IIIa at 40 mg/kg/d by the total packed cell volume method.

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