Studies on Antiatherosclerotic Agents. Synthesis of 5-Substituted Derivatives of 7-Ethoxycarbonyl-6, 8-dimethyl-1(2H)-phthalazinone

Yukuo EGUCHI; Masayuki ISHIKAWA

doi:10.1248/cpb.39.1846

Studies on Antiatherosclerotic Agents. Synthesis of 5-Substituted Derivatives of 7-Ethoxycarbonyl-6, 8-dimethyl-1(2H)-phthalazinone

Yukuo EGUCHI, Masayuki ISHIKAWA

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Keywords: 7-ethoxycarbonyl-6, 8-dimethyl-1(2H)-phthalazinone derivative, antiatherosclerotic agent, diazonium decomposition, 5-fluorine compound

JOURNAL FREE ACCESS

1991 Volume 39 Issue 7 Pages 1846-1848

DOI https://doi.org/10.1248/cpb.39.1846

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Abstract

Several 5-substituted derivatives of 7-ethoxycarbonyl-6, 8-dimethyl-1(2H)-phthalazione were prepared by means of nitration, reductive amination, and diazonium decomposition. The substituents introduced included NO₂, NH₂, F, Cl, CN. Among the derivatives, the fluorine compound was obtained only in poor yield because intramolecular cyclization occurred predominantly.

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