Expression of NG2 proteoglycan in the degenerated intervertebral disc in          dachshunds

Mohammed ABDEL-HAKIEM; Ayuko YAMASHITA; Ayman ATIBA; Yasuhiko OKAMURA; Masaaki KATAYAMA; Haroun YOUSSEF; Hiroshi ISOMURA; Yuji UZUKA

doi:10.1292/jvms.14-0233

Surgery

Expression of NG2 proteoglycan in the degenerated intervertebral disc in dachshunds

Mohammed ABDEL-HAKIEM, Ayuko YAMASHITA, Ayman ATIBA, Yasuhiko OKAMURA, Masaaki KATAYAMA, Haroun YOUSSEF, Hiroshi ISOMURA, Yuji UZUKA

Author information

Mohammed ABDEL-HAKIEM
Division of Veterinary Diagnostic Imaging, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Morioka 020–8550, Japan
Department of Animal Surgery, Faculty of Veterinary Medicine, Assiut University, Assiut 71526, Egypt
Ayuko YAMASHITA
Division of Veterinary Diagnostic Imaging, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Morioka 020–8550, Japan
Ayman ATIBA
Division of Veterinary Diagnostic Imaging, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Morioka 020–8550, Japan
Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt
Yasuhiko OKAMURA
Division of Veterinary Surgery, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Morioka 020–8550, Japan
Masaaki KATAYAMA
Division of Veterinary Diagnostic Imaging, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Morioka 020–8550, Japan
Haroun YOUSSEF
Department of Animal Surgery, Faculty of Veterinary Medicine, Assiut University, Assiut 71526, Egypt
Hiroshi ISOMURA
Pathological Assist, Co., S-1, W-14, Chuo-Ku, Sapporo, Hokkaido 060–0061, Japan
Yuji UZUKA
Division of Veterinary Diagnostic Imaging, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Morioka 020–8550, Japan

Keywords: dachshund, immunohistochemistry, intervertebral disc (IVD) degeneration, NG2 proteoglycan

JOURNAL FREE ACCESS

2016 Volume 78 Issue 1 Pages 97-100

DOI https://doi.org/10.1292/jvms.14-0233

Browse “Advance online publication” version

Details

Abstract

The pathogenesis of intervertebral disc (IVD) degeneration is not fully understood. The biomolecular signaling pathways involved in the IVD degeneration require further investigation. The aim of this study was to investigate the expression of NG2 proteoglycan in the degenerated IVD. IVD samples were obtained from 16 Dachshunds that were confirmed to have IVD herniation and subsequently underwent hemilaminectomy. The samples were subjected to histological and immunohistochemical (IHC) examinations. IHC revealed positive results for the expression of NG2 proteoglycan in all examined samples. The results showed the expression of NG2 proteoglycan by the degenerated IVDs.

Corresponding author

Register with J-STAGE for free!