抄録
Optic tectum derives from the midbrain alar plate in early chick development. To know the molecular mechanism defining tectum territory along the anteroposterior (AP) and dorsoventral (DV) axis in neural development, we have carried out the gain−of−function experiments using a newly developed gene transfer system, in ovo electroporation. Misexpression of Otx2/Gbx2 and Shh changed the expression of tectum−related genes, resulting in the fate change of the tectum structure along the AP axis and the DV axis, respectively. We conclude that these genes are involved in the establishment of tectum territory in embryogenesis.
