抄録
In order to confirm the relationship between glutathione-peroxidase (GSH-PO) localization and biological significance on steroid hormone-producing organs, immunocytochemical localization of GSH-PO in adrenal gland, testis, ovary and prostate of the rat was investigated. GSH-PO was well stained in specific cells of the tissues examined, but staining intensity was altered by the func tional state of the cells. Furthermore, GSH-PO staining was modified by lipoperoxidative damage in tissues or cells. Therefore, we proposed that the pattern of GSH-PO staining should be a more sensitive and specific indicator of oxidative damage in tissues. Thus, the staining pattern of GSH-PO is thought to be a useful marker for lipid peroxidation in the cell.
