A HISTOENZYMOLOGICAL STUDY OF THE PECTORAL MUSCLE FOLLOWING THORACIC X-IRRADIATION
1979 年 12 巻 5 号 p. 451-459
詳細
1979 年 12 巻 5 号 p. 451-459
Histochemical changes in lactate dehydrogenase (LDH), α-glycerophosphate dehydrogenase (α-GPDH), myofibrillar adenosine triphosphatase (ATPase), phosphorylase and glycogen were investigated in pectoral major muscle of guinea pig and albino mouse after 240 R thoracic X-irradiation. The enzymic activities of LDH, α-GPDH and ATPase showed marked reduction at 24, 48 and 72 hrs post-irradiation. Phosphorylase and glycogen, on the other hand, showed an increase in activity, but the damage was severe at 48 and 72 hrs as type I fibers also showed the presence of phosphorylase and glycogen. The phosphorylase reaction emerged from this study as the most sensitive histochemical parameter of radiation injury.
The significance of these alterations with reference to muscle glycolytic energy metabolism after thoracic X-irradiation is discussed.
