1986 年 19 巻 6 号 p. 735-744
An antigen immunologically related to the major core protein (B-p25) of mouse mammary tumor virus (MTV) was identified in Carnoy's fixativetreated human tissue sections by repeated PAP technique. The positive reaction was restricted to the mammary parenchymal cells, and it was completely absent in 42 normal and 20 cancerous tissues other than the breast. Positive findings were obtained in 14/33 normal mature mammary glands, 14/36 cases of mastopathy, 3/12 mammary fibroadenomas and 18/102 mammary carcinomas. The reactivity was not related to the histological types of tumors nor to the age of patients. Antiserum absorption gave support to MTV-specificity of the immunohistochemical reactions observed. It is concluded that normal as well as neoplastic human breast tissues expressed an antigen related to MTV B-p25. However, a B-p25 specific epitope recognized by a monoclonal antibody (83E7) could not be detected in those human tissues investigated.
