EXPRESSION OF PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) IN HUMAN PARATHYROID ADENOMA

抄録

Paraffin-embedded sections of parathyroid adenoma from 27 patients with primary hyperparathyroidism were examined for the expression of proliferating cell nuclear antigen (PCNA). PCNA was expressed on the nuclei of the adenoma cells. The positive rate for PCNA ranged from 0.1% to 2.8% (mean 0.9%). The size of adenomas was not related to the positive rate for PCNA, while the preoperative serum calcium level and positive rate for PCNA revealed statistically the linear regression (y=0.42χ-3.96, p<0.05). Mean level of serum calcium level in the group in which positive rate of PCNA is more than 1.0% is statistically higher than that in the group in which positive rate of PCNA is less than 1.0% (p<0.05).