The interior of a large-size concrete member is heated and cured under high-temperature condition in early ages by internal storage of the heat of cement hydration. This temperature rise of concrete is numerically predicted using the mathematical model for cement hydration and microstructure formation, which has been proposed in our previous study. The hydration rate is predicted using the model. The heat of cement hydration is calculated with its hydration rate. The heat transfer inside the concrete member is simulated by solving a heat conduction equation with heat of cement hydration as the heating element. The predicted concrete temperatures are compared with the concrete temperatures measured in various types of concrete members. The simulation system proposed in this study is useful for predicting the temperature rise of concrete member.