抄録
Chlorpromazine hydrochloride (CP) was measured with octacosane (OC) as an internal standard using a gas chromatograph/mass spectrometer (GC/MS). The integrated intensities were determined by mass chromatograms of many mass-to-charge ratios (m/z values) for each CP and OC. The intensities of the CP were then divided by each intensity of the CP; many intensity ratios were determined. In a multivariate analysis, the intensity ratios having a good correlation were firstly selected from all of the intensity ratios with quantification IV. A principal component analysis was then carried out using the selected intensity ratios; several principal components were determined. Furthermore, in consideration of the eigenvalues for each principal component, unknown concentrations were determined based on the principal component scores. The calculated concentrations of the CP agree well with theoretical concentrations compared with such conventional quantitative methods as the method of least squares or a multiple-regression analysis. A more accurate determination was made possible by the multivariate analysis.
