AMINOGLYCOSIDE ANTIBIOTICS. V

THE 4'-DEOXYBUTIROSINS (BU-1975C₁ AND C₂), NEW AMINOGLYCOSIDE ANTIBIOTICS OF BACTERIAL ORIGIN

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Strains of Bacillus circulans produced the new aminoglycoside antibiotics, 4'-Deoxybutirosins A and B (Bu-1975C₁ and C₂). The new antibiotics C_{21H41N5O11, have physicochemical properties similar to butirosins A and B (C21H41N5O12) with specific differences in TLC and NMR. The antibacterial activity and spectra of 4'-deoxybutirosins are similar to but broader than that of butirosins, inhibiting some butirosin-resistant organisms and showing increased anti-pseudomonal activity. The acute intraveous toxicity of Bu-1975C1 is lower than that of kanamycin and similar to butirosin A.}