CYCLOOCTATIN, A NEW INHIBITOR OF LYSOPHOSPHOLIPASE, PRODUCED BY Streptomyces melanosporofaciens MI614-43F2 TAXONOMY, PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES

TAKAAKI AOYAGI; TAKAYUKI AOYAMA; FUKIKO KOJIMA; SEIKO HATTORI; YOSHIKO HONMA; MASA HAMADA; TOMIO TAKEUCH

doi:10.7164/antibiotics.45.1587

CYCLOOCTATIN, A NEW INHIBITOR OF LYSOPHOSPHOLIPASE, PRODUCED BY Streptomyces melanosporofaciens MI614-43F2

TAXONOMY, PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES

TAKAAKI AOYAGI, TAKAYUKI AOYAMA, FUKIKO KOJIMA, SEIKO HATTORI, YOSHIKO HONMA, MASA HAMADA, TOMIO TAKEUCH

著者情報

ジャーナルフリー

1992 年 45 巻 10 号 p. 1587-1591

DOI https://doi.org/10.7164/antibiotics.45.1587

詳細

抄録

Cyclooctatin has been isolated from Streptomyces melanosporofaciens MI614-43F2 as part of a program designed to find microorganism-produced inhibitors of lysophospholipase. It was purified by chromatography on silica gel, Capcell Pak C₁₈ (HPLC) and Sephadex LH-20 followed by solvent extraction and then isolated as a colorless powder. Cyclooctatin has the molecular formula of C₂₀H₃₄O₃. It is competitive with the substrate, and the inhibition constant (Ki) was 4.8×10^-6M.

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