ANTIGENICITY OF BICYCLOMYCIN ANDI TSC ROSS-REACTIVITWYI THB ENZYLPENICILLIN
1974 年 27 巻 4 号 p. 456-462
詳細
1974 年 27 巻 4 号 p. 456-462
Bicyclomycin was studied for its antigenicity and cross-reactivity with benzylpenicillin. This antibiotic was bound covalently to protein under weakly alkaline conditions. Bicyclomycin or protein conjugates produced antibodies specific to this antibiotic when injected into rabbits, guinea pigs or monkeys as shown by passive hemagglutination, hemagglutination inhibition tests, quantitative precipitin inhibition, and passive cutaneous anaphylaxis. However, no hemagglutinating antibodies were produced in rabbits after continued administration of bicyclomycin by the oral route. There was no cross-reactivity between bicyclomycin and benzylpenicillin by passive hemagglutination or inhibition tests, quantitative precipitin inhibition, and passive cutaneous anaphylaxis reaction.
Bicyclomycin is a new antibiotic active against gram-negative bacilli. The chemical structure, antimicrobial activity and other properties of this antibiotic have been described1. 2.3.4). The present paper deals with its antigenic activity, production of circulating antibodies in experimental animals, and study of elicitation its cross-reactivity with benzylpenicillin.
