STUDY ON TUBERACTINOMYCIN-N. I
IN VITRO ANTIBACTERIAL ACTIVITY OF TUM-N ON TUBERCLE BACILLI ISOLATED FROM PATIENTS
1974 年 27 巻 4 号 p. 463-470
詳細
1974 年 27 巻 4 号 p. 463-470
Tuberactinomycin-N (TUM-N) is an antibiotic isolated from the culture filtrate of Streptomyces griseoverticillotus var. tuberactius N 6-130 by ANDO et al. of Toyo Jozo Co., Ltd. A report has been published1) to demonstrate its remarkable antibiotic activity against tubercle bacilli and to prove the therapeutic effect equivalent to that of viomycin (VM) in experimental tuberculosis of mice and guinea pigs2). Its ototoxicity was reported to be lower than that of VM, capreomycin (CPM) and kanamycin (KM) in its study on guinea pigs3). Its clinical effect was studied in the cases resistant to the conventional anti-tuberculous drugs and found that TUM-N is effective and has little side effect4, 5).
The author presents in this paper the test results obtained from his observation of the in vitro antibacterial activity of TUM-N and other conventional antituberculous drugs against 100 strains of tubercle bacilli isolated from the patients who had never been submitted to TUM-N treatment.
