耳鼻咽喉科領域における持続性Amoxicillin製剤に関する基礎的, 臨床的研究
1982 年 35 巻 5 号 p. 1351-1361
詳細
1982 年 35 巻 5 号 p. 1351-1361
Fundamental and clinical evaluations of a new continual penicillin, C-AMOX, were performed.
The results obtained were as follows.
1.Concentration in serum: The level of serum concentration after giving500mg of oral C-AMOX was determined in3cases of health adult.The maximal level measured4.8μg/ml at4hours after oral administration.Even8hours after oral administration, clinically effective serum C-AMOX concentration1.6μg/ ml was still demonstrable.
2.Concentration of tissues: At4hours after a single oral dose of500mg, the concentration in the tissues of palatine tonsilla was0.6μg/g as against4.9μg/ml in the serum, and the concentration in the tissues of mucous membrane of maxillary sinus was0.5μg/g when measured4.6μg/ml in the serum.
3.Results of clinical treatment: C-AMOX of oral administration was tested in46cases of usually encountered acute and chronic infections in the otorhinolaryngologic field, the results being excellent in25cases, good in14cases and fair in6cases.When the excellent and good were bracketed together, it amounts to39cases (84.8%).It can be considered as high effective ratio.No side effect was shown with the oral administration of C-AMOX.
