TOXICOLOGICAL STUDIES ON A NEW MACROLIDE ANTIBIOTIC, MIDECAMYCIN ACETATE (MIOCAMYCIN)

PART I-1. ACUTE TOXICITY IN MICE

抄録

Miocamycin (MOM) is a derivative of midecamycin, a macrolide antibiotic isolated from a culture broth of Streptomyces mycarofaciens1, 2).
The objective of this study was to determine the acute toxicity of MOM, non-crystalline solid, in male and female mice (Jcl-ICR, SPF, 5-week-old) after single i. p., s. c. and p. o. administration of this material at a dose level of 5,000mg/kg as the maximum physically applicable dose.
MOM, non-crystalline solid, exhibited no acute toxicity in the present study. LD₀ values were estimated as more than 5,000mg/kg in each route of administration.