TOXICOLOGICAL STUDIES ON A NEW MACROLIDE ANTIBIOTIC, MIDECAMYCIN ACETATE (MIOCAMYCIN)

PART I-2. ACUTE TOXICITY IN RATS

抄録

Miocamycin (MOM) is a derivative of midecamycin, a macrolide antibiotic isolated from a cul-ture broth of Streptomyces mycarofaciens1, 2). The object of this study was to determine the acute toxicity in male and female rats (Wistar, 5-week-old) after single i. p., s. c. and p. o. administration of MOM, non-crystalline solid, at a dose level of 5,000mg/kg as the maximum physically applicable dose.
Observations were kept for 1 week after administration.
In conculusion, no animal died during an observation period for 1 week so that the LD₀ values were estimated to be more than 5,000mg/kg in all routes of administration.