TOXICOLOGICAL STUDIES ON A NEW MACROLIDE ANTIBIOTIC, MIDECAMYCIN ACETATE (MIOCAMYCIN) PART III-3. CHRONIC TOXICITY IN BEAGLE DOGS: 26-WEEK-TREATMENT IN FEMALE DOGS

MASAYUKI YOKOTA; UETO TAKEDA; MASUZO ODAKI; HITOSHI SASAKI; TETSUTARO NIIZATO; HARUO KAWAOTO; KAZUNOBU KUMAGAI; HEIJIRO SUZUKI; MIDORI SUZUKI; NORIKO SUGIYAMA; TAKEMI KOEDA

doi:10.11553/antibiotics1968b.37.1383

TOXICOLOGICAL STUDIES ON A NEW MACROLIDE ANTIBIOTIC, MIDECAMYCIN ACETATE (MIOCAMYCIN)

PART III-3. CHRONIC TOXICITY IN BEAGLE DOGS: 26-WEEK-TREATMENT IN FEMALE DOGS

MASAYUKI YOKOTA, UETO TAKEDA, MASUZO ODAKI, HITOSHI SASAKI, TETSUTARO NIIZATO, HARUO KAWAOTO, KAZUNOBU KUMAGAI, HEIJIRO SUZUKI, MIDORI SUZUKI, NORIKO SUGIYAMA, TAKEMI KOEDA

著者情報

MASAYUKI YOKOTA
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
UETO TAKEDA
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
MASUZO ODAKI
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
HITOSHI SASAKI
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
TETSUTARO NIIZATO
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
HARUO KAWAOTO
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
KAZUNOBU KUMAGAI
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
HEIJIRO SUZUKI
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
MIDORI SUZUKI
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
NORIKO SUGIYAMA
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
TAKEMI KOEDA
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.

ジャーナルフリー

1984 年 37 巻 7 号 p. 1383-1397

DOI https://doi.org/10.11553/antibiotics1968b.37.1383

詳細

抄録

Miocamycin (MOM) is a derivative of midecamycin, a macrolide antibiotic1, 2) isolated from a culture broth of Streptomyces mycarofaciens3, 4).
The objective of this study was to determine the chronic toxicity of MOM in female Beagle dogs after once daily repeated p. o. administration of MOM, non-crystalline solid, for 26 weeks at daily dosages of 100, 200 and 400mg/kg.
It is concluded that MOM, non-crystalline solid, did not show any toxic effects in this study and the maximum non-toxic dose is presumed to be 400mg/kg or more in female Beagle dogs administered once daily for 26 weeks.

責任著者(Corresponding author)

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