TOXICOLOGICAL STUDIES ON A NEW MACROLIDE ANTIBIOTIC, MIDECAMYCIN ACETATE (MIOCAMYCIN) PART III-2. CHRONIC TOXICITY IN BEAGLE DOGS: 13-WEEK-TREATMENT IN MALE DOGS

MASAYUKI YOKOTA; UETO TAKEDA; MASUZO ODAKI; HITOSHI SASAKI; TETSUTARO NIIZATO; HARUO KAWAOTO; KAZUNOBU KUMAGAI; HEIJIRO SUZUKI; MIDORI SUZUKI; NORIKO SUGIYAMA; TAKEMI KOEDA

doi:10.11553/antibiotics1968b.37.1377

TOXICOLOGICAL STUDIES ON A NEW MACROLIDE ANTIBIOTIC, MIDECAMYCIN ACETATE (MIOCAMYCIN)

PART III-2. CHRONIC TOXICITY IN BEAGLE DOGS: 13-WEEK-TREATMENT IN MALE DOGS

MASAYUKI YOKOTA, UETO TAKEDA, MASUZO ODAKI, HITOSHI SASAKI, TETSUTARO NIIZATO, HARUO KAWAOTO, KAZUNOBU KUMAGAI, HEIJIRO SUZUKI, MIDORI SUZUKI, NORIKO SUGIYAMA, TAKEMI KOEDA

著者情報

MASAYUKI YOKOTA
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
UETO TAKEDA
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
MASUZO ODAKI
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
HITOSHI SASAKI
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
TETSUTARO NIIZATO
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
HARUO KAWAOTO
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
KAZUNOBU KUMAGAI
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
HEIJIRO SUZUKI
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
MIDORI SUZUKI
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
NORIKO SUGIYAMA
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
TAKEMI KOEDA
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.

ジャーナルフリー

1984 年 37 巻 7 号 p. 1377-1382

DOI https://doi.org/10.11553/antibiotics1968b.37.1377

詳細

抄録

Miocamycin (MOM) is a derivative of midecamycin, a macrolide antibiotic isolated from a culture broth of Streptomyces mycarofaciens1, 2).
The objective of this study was to determine the chronic toxicity of MOM in male Beagle dogs after once daily repeated p. o. administration of MOM, non-crystalline solid, for 13 weeks at daily dosage of 200 and 400mg/kg.
It is concluded that no toxic effects of MOM, non-crystalline solid, were shown in the present studies.
Therefore, the maximum non-toxic dose is presumed to be 400mg/kg or more in male Beagle dogs administered p. o. once daily for 13 weeks.

責任著者(Corresponding author)

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