抄録
The secretory mechanism of pancreatic cells of rats in the case of administration of various kinds of fats, was partly reported in the proceeding section. In this paper results obtained by supplemental experiments performed with pure fatty acid (more purified than material of previous studies), carotin (provitamine A or lipoid) and a mixture of glycerin and fatty acids.
In the case of the administration of sesame oil, the zymogen granules of pancreatic cells are discharged and produced vigorously, and these functions reach a maximum point at 1 1/2 hours after supply. By administration of lipoid, the zymogen granules are produced and discharged under a similar course as in the case of sesame oil. The functional image assumes a rather undertone as compared with the case of sesame oil. By the administration of glycerin, few zymogen granules are produced and discharged, and these phenomena reach a maximum point after an hour and the image becomes further undertone as compared with the sesame oil case.
The fact that few zymogen granules are produced at the beginning of administration of a saturated fatty acid and that zymogen granules and mitochondria show no peculiar changes indicates that the pancreatic cells are in a somewhat stimulated state of its secretory function. Yet the pancreatic cells are clearly exicited by unsaturated fatty acid and zymogen granules are vigorously produced and discharged. But the function is in an undertone as compared with the sesame oil case with a somewhat delay at the beginning of administration.
In the case of administration of a mixture of glycerin and stearic acid, the pancreatic cells are slightly excited and its appeance differs from the cases of either of the above mentioned. The zymogen granules are similar as when given saturated fatty acid and mitochondria are similar as when given unsaturated fatty acid.
