Importance of CALLY Scores in Predicting Coronary Artery Bypass Grafting Outcomes

抄録

Purpose: This study aimed to clarify the importance of C-reactive protein (CRP)–albumin–lymphocyte (CALLY) index scores in predicting coronary artery bypass grafting (CABG) outcomes.

Methods: Patients were divided into quartiles (Q1–Q4) based on their preoperative CALLY index values. Preoperative demographic data, laboratory parameters, operative, and postoperative outcomes were recorded.

Results: The CALLY index, a composite marker incorporating CRP, albumin, and lymphocyte levels, increased progressively from Q1 to Q4, showing a statistically significant upward trend (p = 0.001). Operative and postoperative data revealed that intensive care unit (ICU) stay and hospital stay were significantly shorter in Q3 and Q4 compared to Q1 and Q2 groups (p = 0.001 for both). Furthermore, major adverse cardiac and cerebrovascular events (MACCE) rates were significantly reduced in Q3 and Q4 groups (p = 0.001), reinforcing the prognostic utility of the CALLY index. Two-year mortality also demonstrated a statistically significant reduction in the higher quartiles (p = 0.039), while in-hospital mortality did not differ significantly (p = 0.330). Operation time, cross-clamp time, and requirements for inotropic support were similar across all groups (p >0.05). The receiver-operating characteristic curve analysis demonstrated the discriminative ability of the CALLY index in predicting 2-year mortality. Area under the curve was 0.675 (95% confidence interval: 0.607–0.743), indicating moderate predictive performance.

Conclusion: This study revealed that patients with higher CALLY index scores who underwent CABG had significantly shorter hospital and ICU stays. Moreover, MACCE ratio and mortality rate in the first 2 years after CABG were significantly lower in patients with higher CALLY scores.