Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Food & Nutrition Science Regular Papers
Protective Effects of Dietary Nasunin on Paraquat-induced Oxidative Stress in Rats
Yuriko KIMURAYumi ARAKIAsako TAKENAKAKiharu IGARASHI
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1999 Volume 63 Issue 5 Pages 799-804

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Abstract

  The preventive effects of nasunin (delphinidin-3-[4-p-coumaroyl-rhamnosyl(1→6)glucoside]-5-glucoside) on paraquat-induced oxidative stress were determined in rats. Decreased food intake and body weight gain and increased lung weight by feeding the rats a diet containing paraquat were clearly suppressed by supplementing nasunin to the paraquat diet. Paraquat feeding increased the concentration of thiobarbituric acid-reactive substances (TBARS) in liver lipids and the atherogenic index, and decreased the liver triacylglycerol level. These effects were also suppressed by supplementing nasunin to the paraquat diet. In addition, catalase activity in the liver mitochondrial fraction was markedly decreased by feeding the paraquat diet, this decrease being partially suppressed by supplementing the paraquat diet with nasunin. These results suggest that nasunin acted preventively against the oxidative stress in vivo that may have been due to active oxygen species formed through the action of paraquat.

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© 1999 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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