Synthesis and Absolute Configuration of MQ-A₃ [1-(14'-Methylhexadecanoyl) pyrrolidine], a Novel Aliphatic Pyrrolidine Amide from the Tropical Convolvulaceous Species

Abstract

A novel pyrrolidine amide (MQ-A₃) isolated from the tropical convolvulaceous species was synthesized in 5 steps by starting from commercially available 12-bromododecanol and (S)-2-methylbutylbromide. The absolute configuration of the natural product was confirmed by a comparison of the specific rotation values.