Aplysiallene, a New Bromoallene as an Na, K-ATPase Inhibitor from the Sea Hare, Aplysia kurodai

Yoshihiro OKAMOTO; Naoko NITANDA; Makoto OJIKA; Youji SAKAGAMI

doi:10.1271/bbb.65.474

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Organic Chemistry

Aplysiallene, a New Bromoallene as an Na, K-ATPase Inhibitor from the Sea Hare, Aplysia kurodai

Yoshihiro OKAMOTO, Naoko NITANDA, Makoto OJIKA, Youji SAKAGAMI

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Keywords: aplysiallene, Aplysia kurodai, Na,K-ATPase, enzyme inhibitors, marine metabolites

JOURNAL FREE ACCESS

2001 Volume 65 Issue 2 Pages 474-476

DOI https://doi.org/10.1271/bbb.65.474

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Abstract

A new bromoallene metabolite, named aplysiallene, was isolated from the Japanese sea hare, Aplysia kurodai, as an Na,K-ATPase inhibitor. Its structure was elucidated by spectroscopic methods. The known metabolites, laurinterol and debromolaurinterol, isolated from this animal were also evaluated for their Na,K-ATPase inhibitory activity.

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