Gnetol as a Potent Tyrosinase Inhibitor from Genus Gnetum

Kenji OHGUCHI; Toshiyuki TANAKA; Ibrahim ILIYA; Tetsuro ITO; Munekazu IINUMA; Kenji MATSUMOTO; Yukihiro AKAO; Yoshinori NOZAWA

doi:10.1271/bbb.67.663

Biochemistry & Molecular Biology Preliminary Communication

Gnetol as a Potent Tyrosinase Inhibitor from Genus Gnetum

Kenji OHGUCHI, Toshiyuki TANAKA, Ibrahim ILIYA, Tetsuro ITO, Munekazu IINUMA, Kenji MATSUMOTO, Yukihiro AKAO, Yoshinori NOZAWA

著者情報

キーワード: tyrosinase, melanin, gnetaceae, gnetol

ジャーナルフリー

2003 年 67 巻 3 号 p. 663-665

DOI https://doi.org/10.1271/bbb.67.663

詳細

抄録

Gnetol (2,3′,5′,6-tetrahydroxy-trans-stilbene), a naturally occurring compound particularly found in the genus Gnetum, had a strong inhibitory effect on murine tyrosinase activity. Gnetol (IC₅₀, 4.5 μM) was stronger than kojic acid (IC₅₀, 139 μM) as a standard inhibitor for murine tyrosinase activity. Moreover, gnetol significantly suppressed melanin biosynthesis in murine B16 melanoma cells.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）