Fosmidomycin Resistance in Adenylate Cyclase Deficient (cya) Mutants of Escherichia coli

Yoshiko SAKAMOTO; Soichi FURUKAWA; Hirokazu OGIHARA; Makari YAMASAKI

doi:10.1271/bbb.67.2030

Microbiology & Fermentation Technology Notes

Fosmidomycin Resistance in Adenylate Cyclase Deficient (cya) Mutants of Escherichia coli

Yoshiko SAKAMOTO, Soichi FURUKAWA, Hirokazu OGIHARA, Makari YAMASAKI

著者情報

キーワード: fosmidomycin, cAMP, Escherichia coli, DNA micro-array

ジャーナルフリー

2003 年 67 巻 9 号 p. 2030-2033

DOI https://doi.org/10.1271/bbb.67.2030

詳細

抄録

Adenylate cyclase deficient (cya) mutants of E. coli K-12 were found to be resistant to fosmidomycin, a specific inhibitor of the non-mevalonate pathway, just like to fosfomycin. E. coli glpT mutants were resistant to fosfomycin and also to fosmidomycin. This fact shows that fosmidomycin was transported inside via the glycerol-3-phosphate transporter, GlpT. DNA micro-array analysis showed that the transcription of glpT and other genes concerning glycerol utilization were highly dependent on the presence of cAMP.

責任著者(Corresponding author)

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