Ursolic Acid Enhances Cyclooxygenases and Tumor Necrosis Factor-α Expression in Mouse Skin

Yasutaka IKEDA; Akira MURAKAMI; Takashi NISHIZAWA; Hajime OHIGASHI

doi:10.1271/bbb.70.1033

Food & Nutrition Science Notes

Ursolic Acid Enhances Cyclooxygenases and Tumor Necrosis Factor-α Expression in Mouse Skin

Yasutaka IKEDA, Akira MURAKAMI, Takashi NISHIZAWA, Hajime OHIGASHI

著者情報

キーワード: ursolic acid, inflammation, cyclooxygenase, tumor necrosis factor-α, 12-O-tetradecanoylphorbol-13-acetate

ジャーナルフリー

2006 年 70 巻 4 号 p. 1033-1037

DOI https://doi.org/10.1271/bbb.70.1033

詳細

抄録

An anti-inflammatory triterpenoid, ursolic acid (UA), has recently been found unexpectedly to induce the release of a pro-inflammatory mediator in resting macrophages. In this study, we found that topical applications of UA to mouse skin twice a week for 2 weeks significantly enhanced mRNA expression of cyclooxygenase (COX)-1, COX-2, and tumor necrosis factor-α, whereas its effect on tumor promotion was unclear.

責任著者(Corresponding author)

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