A Role of a Lymphocyte Tryptase, Granzyme A, in Experimental Ulcerative Colitis

Hirofumi HIRAYASU; Yumiko YOSHIKAWA; Satoshi TSUZUKI; Tohru FUSHIKI

doi:10.1271/bbb.60354

Food & Nutrition Science Notes

A Role of a Lymphocyte Tryptase, Granzyme A, in Experimental Ulcerative Colitis

Hirofumi HIRAYASU, Yumiko YOSHIKAWA, Satoshi TSUZUKI, Tohru FUSHIKI

著者情報

キーワード: granzyme A, cytotoxic T-lymphocytes, ulcerative colitis, dextran sulfate sodium, pancreatic secretory trypsin inhibitor

ジャーナルフリー

2007 年 71 巻 1 号 p. 234-237

DOI https://doi.org/10.1271/bbb.60354

View "Advance Publication" version (January 7, 2007).

詳細

抄録

In the large-intestinal mucosae of rats orally administered dextran sulfate sodium, which induces an enteritis resembling ulcerative colitis (UC), the activity for granzyme A, a lymphocyte tryptase, increased at an earlier stage than that at which UC markers (growth-regulated gene product/cytokine-induced neutrophil chemoattractant-1 and caspase-3) increased. This suggests involvement of the enzyme in the exacerbation and perpetuation of enteritis.

責任著者(Corresponding author)

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