Structure-Activity Relationship Study of the Bacterial Actin-Like Protein MreB Inhibitors: Effects of Substitution of Benzyl Group in S-Benzylisothiourea

Noritaka IWAI; Takuya FUJII; Hirokatsu NAGURA; Masaaki WACHI; Tomoya KITAZUME

doi:10.1271/bbb.60443

Biochemistry & Molecular Biology Notes

Structure-Activity Relationship Study of the Bacterial Actin-Like Protein MreB Inhibitors: Effects of Substitution of Benzyl Group in S-Benzylisothiourea

Noritaka IWAI, Takuya FUJII, Hirokatsu NAGURA, Masaaki WACHI, Tomoya KITAZUME

著者情報

キーワード: A22, actin-like protein, benzylisothiourea, MreB, rod-shape determination

ジャーナルフリー
電子付録

2007 年 71 巻 1 号 p. 246-248

DOI https://doi.org/10.1271/bbb.60443

View "Advance Publication" version (January 7, 2007).

詳細

抄録

We comprehensively investigated the effects of substitution of the benzyl group in S-benzylisothiourea derivatives on antibacterial activity, because we found previously that some substitutions enhanced it. A 2,4-Cl₂-derivative was found to be the most effective compound, it was stronger than the original one in Gram-negative rod shaped-bacteria such as Escherichia coli and Salmonella typhimurium.

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