Disruption of Lipid Rafts Enhances the Effect of Lactobacilli on the Production of Tumor Necrosis Factor-Alpha in Mononuclear Blood Cells

Mario SORIA; Mónica MECHOUD; Angela MARTIN DE QUEVEDO; Graciela FONT DE VALDEZ; Ana V. RODRIGUEZ

doi:10.1271/bbb.80445

Microbiology & Fermentation Technology Notes

Disruption of Lipid Rafts Enhances the Effect of Lactobacilli on the Production of Tumor Necrosis Factor-Alpha in Mononuclear Blood Cells

Mario SORIA, Mónica MECHOUD, Angela MARTIN DE QUEVEDO, Graciela FONT DE VALDEZ, Ana V. RODRIGUEZ

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Keywords: lactobacilli, lipid rafts, tumor necrosis factor-alpha

JOURNAL FREE ACCESS

2008 Volume 72 Issue 12 Pages 3293-3296

DOI https://doi.org/10.1271/bbb.80445

View "Advance Publication" version (December 7, 2008).

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Abstract

We investigated, to determine whether disruption of lipid rafts would influence the effect of three selected strains of Lactobacillus on TNF-alpha production by peripheral blood mononuclear cells. Two strains increased TNF-alpha production; and the third one reduced cytokine levels. Disruption of rafts changed the immunomodulatory effect of the three strains. This is the first report on a potential role of rafts in lactobacilli-cell interaction.

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