Surugapyrroles A and B, Two New N-Hydroxypyrroles, as DPPH Radical-Scavengers from Streptomyces sp. USF-6280 Strain

Yasumasa SUGIYAMA; Kei WATANABE; Akira HIROTA

doi:10.1271/bbb.80617

Organic Chemistry Notes

Surugapyrroles A and B, Two New N-Hydroxypyrroles, as DPPH Radical-Scavengers from Streptomyces sp. USF-6280 Strain

Yasumasa SUGIYAMA, Kei WATANABE, Akira HIROTA

著者情報

キーワード: DPPH radical-scavenger, Streptomyces sp. USF-6280, surugapyrrole A, surugapyrrole B, N-hydroxypyrrole

ジャーナルフリー

2009 年 73 巻 1 号 p. 230-232

DOI https://doi.org/10.1271/bbb.80617

View "Advance Publication" version (January 7, 2009).

詳細

抄録

Two new N-hydroxypyrroles, surugapyrroles A and B, were isolated as DPPH radical-scavengers from a culture broth of Streptomyces sp. USF-6280 strain. The structures of the two compounds were elucidated by spectroscopic evidences and derivatization. Their DPPH (2,2-diphenyl-1-picrylhydrazyl) radical-scavenging activity was as high as that of butylhydroxytoluene (BHT): surugapyrrole A, ED₅₀ 50.3 μM; surugapyrrole B, ED₅₀ 75.8 μM.

責任著者(Corresponding author)

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