Synthesis of (2RS,8R,10R)-YM-193221 and an Improved Approach to Tyroscherin, Bioactive Natural Compounds from Pseudallescheria sp.

Ryo KATSUTA; Arata YAJIMA; Ken ISHIGAMI; Tomoo NUKADA; Hidenori WATANABE

doi:10.1271/bbb.100361

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Organic Chemistry Regular Papers

Synthesis of (2RS,8R,10R)-YM-193221 and an Improved Approach to Tyroscherin, Bioactive Natural Compounds from Pseudallescheria sp.

Ryo KATSUTA, Arata YAJIMA, Ken ISHIGAMI, Tomoo NUKADA, Hidenori WATANABE

Author information

Keywords: YM-193221, tyroscherin, total synthesis

JOURNAL FREE ACCESS

2010 Volume 74 Issue 10 Pages 2056-2059

DOI https://doi.org/10.1271/bbb.100361

View "Advance Publication" version (October 7, 2010).

Details

Abstract

Short-step syntheses of (2RS,8R,10R)-YM-193221 (1) and tyroscherin (2), which are biologically active compounds isolated from Pseudallescheria sp., were accomplished in six and eight steps from L-tyrosine. The relative stereochemistry of natural YM-193221 was determined to be 8R^*,10R^*.

Content from these authors

This article cannot obtain the latest cited-by information.

Favorites & Alerts

Corresponding author

Register with J-STAGE for free!