Transient Up-Regulation of Immunity- and Apoptosis-Related Genes in Caco-2 Cells Cocultured with THP-1 Cells Evaluated by DNA Microarray Analysis

Yoko ISHIMOTO; Yuji NAKAI; Hideo SATSU; Mamoru TOTSUKA; Makoto SHIMIZU

doi:10.1271/bbb.90732

Biochemistry & Molecular Biology Notes

Transient Up-Regulation of Immunity- and Apoptosis-Related Genes in Caco-2 Cells Cocultured with THP-1 Cells Evaluated by DNA Microarray Analysis

Yoko ISHIMOTO, Yuji NAKAI, Hideo SATSU, Mamoru TOTSUKA, Makoto SHIMIZU

著者情報

キーワード: coculture, IEX-1, maSigPro, microarray

ジャーナルフリー

2010 年 74 巻 2 号 p. 437-439

DOI https://doi.org/10.1271/bbb.90732

View "Advance Publication" version (February 7, 2010).

詳細

抄録

We analyzed changes in gene expression in Caco-2 cells cocultured with THP-1 cells over time periods of 0, 1, 3, 6, 24, and 48 h using a DNA microarray. Differentially expressed genes extracted with maSigPro indicated that an early defense response and cell death occured at the same time, causing an inflammatory condition.

責任著者(Corresponding author)

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