IgE-Suppressive Activity of (−)-Matairesinol and Its Structure-Activity Relationship

抄録

The IgE-suppressive activity of (−)-matairesinol is demonstrated, and the structure-activity relationship of (−)-matairesinol clarified. 3′,4-Dihydroxy-3,4′-dimethoxylignano-9,9′-lactone showed higher IgE-suppressive activity than (−)-matairesinol without any cytotoxic activity. Some derivatives bearing a longer and more bulky alkoxy group at the 3 or 4 position showed IgE-accelerative activity.