Effect of Lactobacillus pentosus S-PT84 Ingestion on IFN-α Production from Plasmacytoid Dendritic Cells by Virus Stimulation

Takayuki IZUMO; Toshihiro MAEKAWA; Masayuki IDA; Atsuko KISHI; Kaoru AKATANI; Yoshinori KITAGAWA; Yoshinobu KISO

doi:10.1271/bbb.100696

Food & Nutrition Science Notes

Effect of Lactobacillus pentosus S-PT84 Ingestion on IFN-α Production from Plasmacytoid Dendritic Cells by Virus Stimulation

Takayuki IZUMO, Toshihiro MAEKAWA, Masayuki IDA, Atsuko KISHI, Kaoru AKATANI, Yoshinori KITAGAWA, Yoshinobu KISO

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Keywords: S-PT84, interferon-α, plasmacytoid dendritic cell, hemagglutinating virus of Japan (HVJ)

JOURNAL FREE ACCESS

2011 Volume 75 Issue 2 Pages 370-372

DOI https://doi.org/10.1271/bbb.100696

View "Advance Publication" version (February 7, 2011).

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Abstract

We investigated the effect of ingesting Lactobacillus pentosus S-PT84 on the interferon-α (IFN-α) production from splenocytes and plasmacytoid dendritic cells by virus stimulation. IFN-α production by the Lactobacillus pentosus S-PT84 ingestion group was significantly greater under the virus-infected condition than that by the control group. Lactobacillus pentosus S-PT84 could enhance the production of IFN-α which is known as an important cytokine for preventing virus infection. It may therefore become a prophylactic tool against such virus infection.

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