Inhibitory Effect of Dietary Carotenoids on Dinitrofluorobenzene-Induced Contact Hypersensitivity in Mice

Shota SAKAI; Tatsuya SUGAWARA; Takashi HIRATA

doi:10.1271/bbb.110104

Food & Nutrition Science Notes

Inhibitory Effect of Dietary Carotenoids on Dinitrofluorobenzene-Induced Contact Hypersensitivity in Mice

Shota SAKAI, Tatsuya SUGAWARA, Takashi HIRATA

著者情報

キーワード: carotenoid, contact hypersensitivity, ear swelling, mast cell, histamine

ジャーナルフリー

2011 年 75 巻 5 号 p. 1013-1015

DOI https://doi.org/10.1271/bbb.110104

View "Advance Publication" version (May 20, 2011).

詳細

抄録

We evaluated the effect of carotenoids on the dinitrofluorobenzene (DNFB)-induced contact hypersensitivity in mice. Dietary carotenoids significantly inhibited ear swelling and reduced the contents of TNF-α and histamine in the DNFB-treated mice. Our results suggest that dietary carotenoids exerted an anti-inflammatory effect by suppressing mast cell degranulation in vivo.

責任著者(Corresponding author)

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