Rhapontigenin Converted from Rhapontin Purified from Rheum undulatum Enhances the Inhibition of Melanin Synthesis

Hyun-Sun LEE; Jeong-Keun KIM; Keun-Tae PARK; Young-Hee LIM

doi:10.1271/bbb.120229

Food & Nutrition Science Notes

Rhapontigenin Converted from Rhapontin Purified from Rheum undulatum Enhances the Inhibition of Melanin Synthesis

Hyun-Sun LEE, Jeong-Keun KIM, Keun-Tae PARK, Young-Hee LIM

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Keywords: rhapontigenin, bioconversion, tyrosinase, melanin synthesis inhibition, aglycone

JOURNAL FREE ACCESS

2012 Volume 76 Issue 12 Pages 2307-2309

DOI https://doi.org/10.1271/bbb.120229

View "Advance Publication" version (December 7, 2012).

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Abstract

Rhapontigenin was produced from rhapontin isolated from a methanol extract of Rheum undulatum roots by enzymatic transformation. Rhapontin and rhapontigenin exhibited dose-dependent inhibition of tyrosinase activity and melanin synthesis in B16F10 melanoma cells, but the inhibitory activity of rhapontigenin was greater than that of rhapontin. Thus the bioconversion of rhapontin enhanced its ability to inhibit cellular tyrosinase activity and melanin synthesis.

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