Reduction of Overall Helicobacter pylori Colonization Levels in the Stomach of Mongolian Gerbil by Lactobacillus johnsonii La1 (LC1) and Its in Vitro Activities against H. pylori Motility and Adherence

Hirokazu ISOBE; Akihito NISHIYAMA; Tomomi TAKANO; Wataru HIGUCHI; Saori NAKAGAWA; Ikue TANEIKE; Yoichi FUKUSHIMA; Tatsuo YAMAMOTO

doi:10.1271/bbb.110921

Microbiology & Fermentation Technology Notes

Reduction of Overall Helicobacter pylori Colonization Levels in the Stomach of Mongolian Gerbil by Lactobacillus johnsonii La1 (LC1) and Its in Vitro Activities against H. pylori Motility and Adherence

Hirokazu ISOBE, Akihito NISHIYAMA, Tomomi TAKANO, Wataru HIGUCHI, Saori NAKAGAWA, Ikue TANEIKE, Yoichi FUKUSHIMA, Tatsuo YAMAMOTO

著者情報

キーワード: Lactobacillus johnsonii La1 (LC1), Helicobacter pylori, Mongolian gerbil, motility, adherence

ジャーナルフリー

2012 年 76 巻 4 号 p. 850-852

DOI https://doi.org/10.1271/bbb.110921

View "Advance Publication" version (April 7, 2012).

詳細

抄録

The effects of Lactobacillus johnsonii La1 (LC1) on Helicobacter pylori colonization in the stomach were investigated. H. pylori colonization and gastritis in LC1-inoculated Mongolian gerbils were significantly less intense than those in the control animals. LC1 culture supernatant (>10-kDa fraction) inhibited H. pylori motility and induced bacterial aggregation in human gastric epithelial cells, suggesting the potential of clinical use of LC1 product.

責任著者(Corresponding author)

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