Reduction of Overall Helicobacter pylori Colonization Levels in the Stomach of Mongolian Gerbil by Lactobacillus johnsonii La1 (LC1) and Its in Vitro Activities against H. pylori Motility and Adherence

Hirokazu ISOBE; Akihito NISHIYAMA; Tomomi TAKANO; Wataru HIGUCHI; Saori NAKAGAWA; Ikue TANEIKE; Yoichi FUKUSHIMA; Tatsuo YAMAMOTO

doi:10.1271/bbb.110921

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Reduction of Overall Helicobacter pylori Colonization Levels in the Stomach of Mongolian Gerbil by Lactobacillus johnsonii La1 (LC1) and Its in Vitro Activities against H. pylori Motility and Adherence

Hirokazu ISOBE, Akihito NISHIYAMA, Tomomi TAKANO, Wataru HIGUCHI, Saori NAKAGAWA, Ikue TANEIKE, Yoichi FUKUSHIMA, Tatsuo YAMAMOTO

著者情報

Hirokazu ISOBE
Division of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences
Akihito NISHIYAMA
Division of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences
Tomomi TAKANO
Division of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences
Wataru HIGUCHI
Division of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences
Saori NAKAGAWA
Division of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences
Ikue TANEIKE
Division of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences
Yoichi FUKUSHIMA
Nestlé Japan, Ltd., Nutrition Business Group
Tatsuo YAMAMOTO
Division of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences

キーワード: Lactobacillus johnsonii La1 (LC1), Helicobacter pylori, Mongolian gerbil, motility, adherence

ジャーナルフリー早期公開

論文ID: 110921

DOI https://doi.org/10.1271/bbb.110921

この記事には本公開記事があります。

The final version of this article is now available: Vol. 76 (2012) , No. 4 p.850

詳細

抄録

The effects of Lactobacillus johnsonii La1 (LC1) on Helicobacter pylori colonization in the stomach were investigated. H. pylori colonization and gastritis in LC1-inoculated Mongolian gerbils were significantly less intense than those in the control animals. LC1 culture supernatant (>10-kDa fraction) inhibited H. pylori motility and induced bacterial aggregation in human gastric epithelial cells, suggesting the potential of clinical use of LC1 product.

責任著者(Corresponding author)

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