Isolation of 9-Hydroxy-10E,12Z-octadecadienoic Acid, an Inhibitor of Fat Accumulation from Valeriana fauriei

Keiji YUKI; Mariko IKEDA; Kenji MIYAMOTO; Osamu OHNO; Kaoru YAMADA; Daisuke UEMURA

doi:10.1271/bbb.110994

Organic Chemistry Note

Isolation of 9-Hydroxy-10E,12Z-octadecadienoic Acid, an Inhibitor of Fat Accumulation from Valeriana fauriei

Keiji YUKI, Mariko IKEDA, Kenji MIYAMOTO, Osamu OHNO, Kaoru YAMADA, Daisuke UEMURA

著者情報

キーワード: Valeriana fauriei, 3T3-L1 murine adipocytes, inhibitor, fat accumulation

ジャーナルフリー

2012 年 76 巻 6 号 p. 1233-1235

DOI https://doi.org/10.1271/bbb.110994

View "Advance Publication" version (June 7, 2012).

詳細

抄録

An EtOH extract of Valeriana fauriei was found to exhibit potent inhibition of fat accumulation against 3T3-L1 murine adipocytes. After performing several chromatographic steps, we successfully isolated the conjugated linoleic acid derivative, 9-hydroxy-10E,12Z-octadecadienoic acid (9-HODE). Synthesized 9-HODE and its analogs showed inhibitory activity against fat accumulation.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）