Involvement of 5-Methyltetrahydrofolate in the Amelioration of Hyperhomocysteinemia Caused by Vitamin B6 Deficiency and <small>L</small>-Methionine Supplementation

Kohei YAMAMOTO; Yasuka ISA; Tomoyuki NAKAGAWA; Takashi HAYAKAWA

doi:10.1271/bbb.120661

Food & Nutrition Science Notes

Involvement of 5-Methyltetrahydrofolate in the Amelioration of Hyperhomocysteinemia Caused by Vitamin B₆ Deficiency and L-Methionine Supplementation

Kohei YAMAMOTO, Yasuka ISA, Tomoyuki NAKAGAWA, Takashi HAYAKAWA

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Keywords: vitamin B₆ deficiency, hyperhomocysteinemia, methionine synthase, 5-methyltetrahydrofolate, post-methionine load

JOURNAL FREE ACCESS

2013 Volume 77 Issue 2 Pages 378-380

DOI https://doi.org/10.1271/bbb.120661

View "Advance Publication" version (February 7, 2013).

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Abstract

We attempted to clarify the reason why folate fortification ameliorates hyperhomocysteinemia induced by vitamin B₆ deficiency. Hyperhomocysteinemia caused by vitamin B₆ deficiency significantly decreased the rat liver 5-methyltetrahydrofolate level which was significantly improved by folate fortification. This result suggests that the amelioration of hyperhomocysteinemia in response to folate supplementation had enhanced the removal of homocysteine via methionine synthase.

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