Effect of Continuous Ingestion of Acetic Acid Bacteria on Memory Retention and the Synaptic Function in Aged Rats

Hiroyuki FUKAMI; Satoru KOBAYASHI; Hideki TACHIMOTO; Mikiya KISHI; Takayuki KAGA; Hatsue WAKI; Machiko IWAMOTO; Yasukazu TANAKA

doi:10.1271/bbb.100164

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Effect of Continuous Ingestion of Acetic Acid Bacteria on Memory Retention and the Synaptic Function in Aged Rats

Hiroyuki FUKAMI, Satoru KOBAYASHI, Hideki TACHIMOTO, Mikiya KISHI, Takayuki KAGA, Hatsue WAKI, Machiko IWAMOTO, Yasukazu TANAKA

著者情報

キーワード: Acetobacter, sphingolipid, ceramide, memory, synapse

ジャーナルフリー早期公開

論文ID: 100164

DOI https://doi.org/10.1271/bbb.100164

この記事には本公開記事があります。

The final version of this article is now available: Vol. 74 (2010) , No. 7 p.1498

詳細

抄録

We administered Acetobacter malorum NCI1683 (S24), containing a high concentration of dihydroceramide (7.2 mg/g of dry cell weight), consecutively to aged rats (male Crlj:Wistar rats, 22 months old). The ingestion of Acetobacter malorum for 89 d significantly extended the memory retention in passive avoidance tests, increased the release of acetylcholine with depolarization of brain synaptosomes and decreased the causative agents of neurodegenerative diseases in the cerebral cortices.

責任著者(Corresponding author)

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