Effect of Continuous Ingestion of Acetic Acid Bacteria on Memory Retention and the Synaptic Function in Aged Rats

Hiroyuki FUKAMI; Satoru KOBAYASHI; Hideki TACHIMOTO; Mikiya KISHI; Takayuki KAGA; Hatsue WAKI; Machiko IWAMOTO; Yasukazu TANAKA

doi:10.1271/bbb.100164

Food & Nutrition Science Notes

Effect of Continuous Ingestion of Acetic Acid Bacteria on Memory Retention and the Synaptic Function in Aged Rats

Hiroyuki FUKAMI, Satoru KOBAYASHI, Hideki TACHIMOTO, Mikiya KISHI, Takayuki KAGA, Hatsue WAKI, Machiko IWAMOTO, Yasukazu TANAKA

著者情報

キーワード: Acetobacter, sphingolipid, ceramide, memory, synapse

ジャーナルフリー

2010 年 74 巻 7 号 p. 1498-1500

DOI https://doi.org/10.1271/bbb.100164

View "Advance Publication" version (July 7, 2010).

詳細

抄録

We administered Acetobacter malorum NCI1683 (S24), containing a high concentration of dihydroceramide (7.2 mg/g of dry cell weight), consecutively to aged rats (male Crlj:Wistar rats, 22 months old). The ingestion of Acetobacter malorum for 89 d significantly extended the memory retention in passive avoidance tests, increased the release of acetylcholine with depolarization of brain synaptosomes and decreased the causative agents of neurodegenerative diseases in the cerebral cortices.

責任著者(Corresponding author)

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