Effects of Pro-Hyp, a Collagen Hydrolysate-Derived Peptide, on Hyaluronic Acid Synthesis Using in Vitro Cultured Synovium Cells and Oral Ingestion of Collagen Hydrolysates in a Guinea Pig Model of Osteoarthritis

Hiroki OHARA; Hiroyuki IIDA; Kyoko ITO; Yasuo TAKEUCHI; Yoshihiro NOMURA

doi:10.1271/bbb.100193

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Effects of Pro-Hyp, a Collagen Hydrolysate-Derived Peptide, on Hyaluronic Acid Synthesis Using in Vitro Cultured Synovium Cells and Oral Ingestion of Collagen Hydrolysates in a Guinea Pig Model of Osteoarthritis

Hiroki OHARA, Hiroyuki IIDA, Kyoko ITO, Yasuo TAKEUCHI, Yoshihiro NOMURA

著者情報

キーワード: proline-hydroxyproline (Pro-Hyp), hyaluronic acid, collagen hydrolysates, osteoarthritis, proteoglycan

ジャーナルフリー早期公開

論文ID: 100193

DOI https://doi.org/10.1271/bbb.100193

この記事には本公開記事があります。

The final version of this article is now available: Vol. 74 (2010) , No. 10 p.2096

詳細

抄録

Proline-hydroxyproline (Pro-Hyp) stimulated hyaluronic acid production in cultured synovium cells. It was detected in guinea pig blood after oral ingestion of collagen hydrolysates. Oral administration of collagen hydrolysates increased the amount of proteoglycans in the epiphyses. It also reduced the morphological changes associated with osteoarthritic cartilage destruction of the knee joint. The results suggest that collagen hydrolysates have therapeutic potential for treatment of osteoarthritis.

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